This Learning Showcase outlines the core components of a Clinical Knowledge Management (CKM) program and explains why healthcare organizations should use state-of-the-art tools to create and manage knowledge assets. Success stories and specific examples from past projects will be described. Knowledge represented as interconnected computable assets are essential building blocks of EHR systems. Clinical knowledge management ensures that knowledge assets within an entire institution are accurate and up-to-date. Proactively managing and maintaining knowledge assets creates a solid foundation for EHR systems to help improve patient safety, quality of care, and billing. CKM can improve efficiency and prevent malfunctions of knowledge-driven EHR features such as clinical decision support, order sets, care documentation, and access to reference content. Knowledge assets are interconnected through a complex web of dependencies. Without efficient tools and processes to adequately manage the dependencies, a change to a single knowledge asset can cause multiple unnecessary EHR malfunctions. Despite the increasing sophistication of EHR systems, healthcare organizations are underinvesting in specialized tools and resources to effectively manage knowledge assets.